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Understanding the modulation of contextual fear learning and memory by the neurotransmitter dopamine is important as it could lead to a greater understanding of the mechanisms underlying anxiety disorders. The effect of D1 receptor antagonism during the contextual fear learning and memory stages was investigated. This experiment was followed up by investigating the effects of SCH 23390 infusion into the dorsal hippocampus (5g per side) or amygdala (2.5g per side) on contextual fear acquisition.

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